2007 OMIG, Abstract 13

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Utilizing a Hydrophilic Intraocular Lens for Intraocular Drug Delivery
Lisa M. Nijm^1*, Elmer Y. Tu¹, Lawrence J. Ulanski, II¹ Rick Fiscella, Jr.¹, Randall Peterson².
¹Department of Ophthalmology, University of Illinois Eye and Ear Infirmary, Chicago, IL;
²Springfield Clinic Eye Institute, Springfield, IL.

Purpose: To determine whether implanting a STAAR Collamer hydrophilic intraocular lens (IOL), soaked in moxifloxacin 0.5% or gatifloxacin 0.3%, would result in release of sufficient antibiotic to effectively inhibit the most common pathogens that cause endophthalmitis. 
Methods: STAAR Collamer IOLs were immersed in commercially available moxifloxacin 0.5% or gatifloxacin 0.3% and implanted in the capsular bag of 11 rabbit eyes after evacuation of the crystalline lens.  Aqueous humor samples were taken at 30 minutes, 2 hours, 4 hours, 6 hours, and 24 hours and antibiotic levels were measured using HPLC.
Results: The average peak concentration of moxifloxacin was 71.3 µg/mL at 2.18 hours with a standard deviation of ± 23.4 µg/mL.  At 24 hours, the average concentration was 7.1 µg/mL with a standard deviation of ± 5.87 µg/mL.  For those lenses soaked between 1-5 hours, the average rate of elimination was –0.125 µg/mL ±  0.022 and for those lenses soaked for 15.5-16.5 hours, the average rate of elimination was  -0.60 µg/mL ±  0.023.  The average peak concentration of gatifloxacin was 36.2µg/mL with a standard deviation of ±1.12µg/mL.  At 24 hours, the average concentration of gatifloxacin was 0.69 µg/mL ±  0.09.  The lenses soaked in gatifloxacin ranged from 0.67 to 4.25 hrs.  
Conclusions:
·  Implanting a STAAR Collamer hydrophilic intraocular lens, soaked in moxifloxacin or gatifloxacin, resulted in release of a high level of antibiotic that greatly exceeded the MIC₉₀ for most of the common pathogens that cause endophthalmitis. 
·  Concentrations of the antibiotic in the aqueous humor seemed to correlate with relative soak times and starting concentrations of each respective antibiotic. 
·  This research demonstrates that at least one type of hydrophilic intraocular lens may be utilized as a drug delivery system for the prevention of endophthalmitis.

Disclosure:  This project was supported, in part, by an unrestricted grant from the Illinois Society for the Prevention of Blindness.

Disclosure code: F

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